By Tim Rose, Cassandra Bain, 9news.au.com

Women and children are among five people found dead inside a Perth home, the third mass tragedy to rock Western Australia this year.

Homicide detectives went to the home on Coode Street in Bedford today after a man in his 20s handed himself into a regional police station.

WA Police Assistant Commissioner Paul Steel said “up to five” people were found dead, including women and children.

“This is a tragic event and it will no doubt have an impact not only on the family and friends of the deceased but for the whole of the community and those first responders who are faced with attending a scene of multiple deceased people,” he said.

He added police were still examining the home for evidence and could not provide further details on the victims.

9NEWS understands at least three young children are among the dead.

The man who attended the regional police station is now in custody and there are no ongoing concerns for public safety.

Neighbours expressed their shock this afternoon as the heavy police presence remained on the suburban street.

“It’s just really sad that something like this can happen in such a quiet neighbourhood, it’s horrid on every level … poor children,” resident Maria Manfredini said.

Locals said children were often seen playing in the front yard of the home.

“Yeah pretty upset, I have two kids myself and when something happens too close it’s really distressing,” Wagner D’Souza said.

The deaths follow the murder of a mother and her two children in Ellenbrook in July, and the Margaret River mass shooting that left seven people dead in May.

“It is a tragic thing when incidents like this occur,” Asst Comm. Steel said.

“It does send a ripple through the community of Western Australia.”